It all started when Charlie Logan was ten years old. Breaking the cardinal rules of spin-the-bottle, Charlie refused to lip-lock with a demented Goth girl and she put a hex on him. Now, twenty-five years later, Charlie (Dane Cook) is a successful dentist and still cursed.
While his plastic surgeon best friend, Stu (Dan Fogler), pursues as many of his patients as possible, Charlie can t seem to find the right girl. Even worse, he discovers at an ex-girlfriend s wedding that every woman he s ever slept with has found true love with the next guy after him. Before he knows it, Charlie s reputation as a good luck charm has women from sexy strangers to his overweight receptionist lining up for a quickie.
But a life filled with all sex and no love has Charlie lonelier than ever that is, until he meets Cam (Jessica Alba). An accident-prone penguin specialist, Cam is as hard-to-get as she is beautiful. But when a genuine romance develops, Charlie realizes he s got to find a way to break his good-luck curse before the girl of his dreams winds up with the next guy she meets.
It all started when Charlie Logan was ten years old.